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Chiron Vaccines
N19 polyepitope enhances immunogenicity of combined conjugate vaccines
October 26th, 2005
The N19 polyepitope as a carrier protein enhances the immunogenicity of combined conjugate vaccines. "The N19 polyepitope, consisting of a sequential string of universal human CD4+ T-cell epitopes, was tested as a carrier protein in a formulation of combined glycoconjugate vaccines containing the capsular polysaccharides (PSs) of Neisseria meningitidis serogroups A, C, W-135, and Y. Good antibody responses to all four polysaccharides were induced by one single immunization of mice with N19-based conjugates," scientists writing in the journal Infection and Immunity report. "Two immunizations with N19 conjugates elicited anti-MenACWY...
Source: Elder Law Weekly (2005-10-26)
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