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Harvard Medical School
HIV-1 L74V enhances AZT susceptibility by removing ATP-dependent phosphorolysis
October 26th, 2005
The HIV-1 L74V mutation enhances AZT susceptibility by removing ATP-dependent phosphorolysis. "Thymidine analog mutations (TAMs) in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) confer resistance to zidovudine (AZT) by increasing the rate of ATP-dependent phosphorolysis of the terminal nucleotide monophosphate (primer unblocking). "By contrast, the L74V mutation, which confers resistance to didanosine, sensitizes HIV-1 to AZT and partially restores AZT susceptibility when present together with one or more TAMs," investigators in the United States report. "To compare rates of primer unblocking in RTs...
Source: Elder Law Weekly (2005-10-26)
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