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Chinese Academy of Medical Science, Beijing
Indole amide analogues examined, histone deacetylase inhibition revealed
October 26th, 2005
A study from the People's Republic of China has presented an exploration of a binding mode of indole amide analogues as potent histone deacetylase inhibitors and three-dimensional quantitative structure-activity relationship (3D-QSAR) analyses. "Docking simulations and 3D-QSAR analyses were conducted on a series of indole amide analogues as potent histone deacetylase inhibitors. The studies include comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)," wrote Y.S. Guo and colleagues, Chinese Academy of Medical Science, Beijing. "Selected ligands were docked into the active site of human HDAC1....
Source: Elder Law Weekly (2005-10-26)
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