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Taipei Veterans General Hospital

Adenosine receptor polymorphism is not linked to Parkinson disease and schizophrenia

Published in Elder Law Weekly, December 21st, 2005

Recent research from Taiwan has documented association studies of the adenosine A2a receptor genetic polymorphism in Parkinson disease (PD) and schizophrenia.

C.J. Hong and colleagues, Taipei Veterans General Hospital, wrote, "Given the implications with respect to the pathogenesis of dopaminergic dysfunction in schizophrenia and PD, as well as the reciprocal antagonistic interactions between adenosine A2a receptor (A2aAR) and the dopamine D2 receptors, A2aAR may be a candidate gene conferring susceptibility to PD or schizophrenia."

"In this study, we tested the hypothesis that the A2aAR 1976T >C genetic variant confers susceptibility to or is...

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