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Stockholm University

Low oxygen levels do not increase cold-induced VEGF in brown adipose tissue

Published in Elder Law Weekly, December 21st, 2005

Low oxygen levels do not increase cold-induced vascular endothelial growth factor (VEGF) in brown adipose tissue.

Scientists in Sweden conducted a study "to examine whether cold-induced VEGF gene expression in brown adipose tissue involved generation of hypoxic oxygen levels by thermogenic processes, we cold-exposed wild-type mice, as well as uncoupling protein-1 (UCP1)-ablated mice in which no thermogenesis in brown adipocytes can be induced."

"Cold exposure stimulated VEGF expression in both wild-type and UCP1-ablated mice. Unexpectedly, the effect was 3-fold higher in UCP1-ablated animals, whereas cultured brown adipocytes from both genotypes...

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