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University of Nebraska Medical Center

Secreted HIV gp120 proteins induce lung endothelial cell injury

Published in Elder Law Weekly, December 21st, 2005

Secreted HIV gp120 proteins induce lung endothelial cell injury and may contribute to the development of pulmonary hypertension.

According to recent research from the United States, "Pulmonary hypertension associated with human immunodeficiency virus (HIV) infection also involves injury to the lung endothelium. However, the pathogenesis of HIV-induced pulmonary hypertension is not known.

"We hypothesized that HIV or secreted viral proteins could play a role in vascular injury and the increased frequency of pulmonary hypertension observed in HIV-infected patients."

"Here, we report that exposure of HIV-1 gp120 proteins to primary...

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