Hiroshima University, Japan
Gastrointestinal stromal tumors with KIT gene mutations are more likely to metastasize
Published in Elder Law Weekly, July 26th, 2006
According to a study from Japan, "The goal of this study was to investigate the association of mutations in the KIT gene and the platelet-derived growth factor receptor alpha (PDGFRA) gene with clinicopathological features of patients with GIST localized in the stomach. We evaluated 56 gastric GISTs for KIT and PDGFRA mutations."
"DNA was extracted from paraffin-embedded tumor specimens, and exons 9, 11, 13 and 17 of the KIT gene and exons 12 and 18 of the PDGFRA gene were amplified by polymerase chain reaction and sequenced. The genetic features were then...
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Source: Elder Law Weekly (2006-07-26)
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