Published in FDA Law Weekly, June 10th, 2004
"A major drawback of current approaches to antiangiogenic gene therapy is the lack of tissue-specific targeting. The aim of this work was to trigger endothelial cell-specific apoptosis, using adenoviral vector-mediated delivery of a chimeric death receptor derived from the modified endothelium-specific pre-proendothelin-1 (PPE-1) promoter. In the present study, we constructed an adenovirus-based vector that targets tumor angiogenesis," researchers in Israel stated.
"Transcriptional control was achieved by use of a modified endothelium-specific promoter. Expression of a chimeric...
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