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Duke Comprehensive Cancer Ctr.

Tamoxifen acts quickly to prevent damaged breast cells from turning cancerous

Published in FDA Law Weekly, December 16th, 2004

Scientists at the Duke Comprehensive Cancer Center at Duke University have discovered a faster and more direct way in which the drug tamoxifen signals damaged breast cells to die.

They are manipulating this pathway with newer and safer drugs designed to prevent breast cancer without triggering the hot flashes and other side effects of tamoxifen.

Tamoxifen is currently the front-line drug to prevent breast cancer, but millions of women do not take it because of its potential to cause hot flashes, mood swings, sleep changes, blood clots, and stroke, said Victoria Seewaldt, MD, lead author of a tamoxifen study published in the November 18, 2004, issue...

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