Dalhousie University

Antibacterial principle of Caesalpina sappan revealed

Published in FDA Law Weekly, December 16th, 2004

A compound from a tree indigenous to India is a potent antimicrobial against a number of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and multi-drug resistant Burkholderia cepacia.

"Using a bioassay-directed purification scheme, the active antibacterial principle from Caesalpina sappan was isolated and identified to be brazilin," wrote H.X. Xu and colleagues, Dalhousie University, Faculty of Dentistry.

The compound showed potent activity, with minimal inhibitory concentrations (MICs) ranging from 4 to 32 mcg/mL.

"[T]ime-kill studies showed that...

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Source: FDA Law Weekly (2004-12-16)

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