EIC Laboratories, Inc.
Star amphiphilic block copolymer developed as drug carrier
Published in FDA Law Weekly, May 26th, 2005
"The core of the star polymer is polyamidoamine (PAMAM) dendrimer, the inner block in the arm is lipophilic poly(epsilon-caprolactone) (PCL), and the outer block in the arm is hydrophilic poly(ethylene glycol) (PEG)," scientists in Massachusetts explained. "The star-PCL polymer was synthesized first by ring-opening polymerization of E-caprolactone with a PAMAM-OH dendrimer as initiator."
"The PEG polymer was then attached to the PCL terminus by an ester-forming reaction," added F. Wang and coauthors working at EIC Laboratories in Norwood....
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Source: FDA Law Weekly (2005-05-26)
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