Boston University
Anticancer prodrug ifosfamide studied
Published in FDA Law Weekly, October 20th, 2005
"The anticancer prodrug IFA contains a chiral phosphorous atom and is administered in the clinic as a racemic mixture of R-IFA and S-IFA. Hepatic cytochrome P450 (P450) enzymes exhibit enantioselective preferences in the metabolism of R-IFA and S-IFA; however, the impact of this selectivity on P450-dependent anticancer activity is not known," investigators in the United States reported.
"Presently, the metabolism and cytotoxicity of R-IFA and S-IFA were determined in 9L gliosarcoma and Chinese hamster ovary tumor cells expressing an IFA-activating P450...
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Source: FDA Law Weekly (2005-10-20)
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