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Allergies Cell Biology
Data from University of Nottingham, Institute of Infection advance knowledge in allergies cell biology
March 15th, 2007
Researchers detail in "The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses," new data in allergies. "The cysteine protease Der p 1 from the house dust mite Dermatophagoides pteronyssinus is one of the most potent allergens known. An attractive mechanism for a component of Der p 1 allergenicity lies in its ability to cleave key regulatory molecules from leucocyte surfaces, subverting cellular function and driving abnormal immunoglobulin E (IgE) responses," scientists in Nottingham, the United Kingdom report. "Although CD23, CD25 and CD40 have already...
Source: FDA Law Weekly (2007-03-15)
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