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Autoimmune Disease Genetics
Research from Imperial College London, Faculty of Medicine broadens understanding of autoimmune disease genetics
March 15th, 2007
Data detailed in "Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice" have been presented. "Extensive evidence indicates that genetic predisposition is a central element in susceptibility to systemic lupus erythematosus both in humans and animals. We have previously shown that a congenic line carrying a 129-derived chromosome 1 interval on the C57BL/6 background developed humoral autoimmunity," scientists writing in the Journal of Immunology report. "To further dissect the contribution to autoimmunity of this 129 interval, we have created six subcongenic strains carrying fractions of the original...
Source: FDA Law Weekly (2007-03-15)
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