Kyoto Prefectural University of Medicine

Researchers report details of new studies and findings in the area of obesity pathogenesis

Published in Fitness and Wellness Business Week, February 9th, 2005

Obesity pathogenesis data are the focus of recent research from Japan and the United States.

Study 1: Growth hormone increases mRNA levels of uncoupling proteins 1, 2, and 3 in brown and white adipose tissues and skeletal muscle in obese mice.

"We have investigated whether GH treatment influences the expression of UCP1, 2 and 3 mRNA in a KK-Ay obese mouse model. KK-Ay mice (n=10) and C57BI/6J control mice (n=10) were injected subcutaneously with human GH (1.0 mg/kg/day and 3.5 mg/kg/day) for 10 days, and compared with mice injected with physical saline. The KK-Ay obese mice weighed significantly less (p<0.01: 1.0 mg/kg/day, p<0.05: 3.5...

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Source: Fitness and Wellness Business Week (2005-02-09)

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