Boston University

Leptin may be involved in placental establishment in early pregnancy

Published in Fitness and Wellness Business Week, February 9th, 2005

Leptin may be involved in placental establishment in early pregnancy, results from a study conducted in mice suggest.

"The hormone leptin is produced by adipose tissue and can function as a signal of nutritional status to the reproductive system. The expression of leptin receptor and, in some species, leptin, in the placenta suggests a role for leptin in placental development, but this role has not been elucidated," said L.C. Schulz and E.P. Widmaier, Boston University.

"Leptin is required at the time of embryo implantation in the leptin-deficient ob/ ob mouse and has been shown to upregulate expression of matrix metalloproteinases (MMPs), enzymes...

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Source: Fitness and Wellness Business Week (2005-02-09)

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