Chung Shan Medical University
Adenosinergic modulation of ventilation impaired in obese Zucker rats
Published in Fitness and Wellness Business Week, July 6th, 2005
"The goal of our study was to determine whether altered adenosinergic mechanisms contribute to the depressed ventilatory response observed in obese Zucker rats.
"Eight lean and eight obese Zucker rats were studied at 7 to 8 weeks of age. Ventilation (VE ) during room air, during 5-minute hypercapnic (7% CO2 , balance O2 ), and during 30-minute sustained hypoxic (10% O2 ) exposures were sequentially measured by the barometric method on three separate occasions after the randomized blinded administration of equal volumes of either...
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