Arthritis

New arthritis findings from M.J. Thiel and co-authors described

Published in Fitness and Wellness Business Week, January 2nd, 2008

Researchers in the United States conducted a study "To evaluate the role of the MEK/ERK MAP kinase pathway in murine collagen-induced arthritis (CIA) using the selective MEK inhibitor PD184352. We examined the effects of the inhibitor in cytokine-stimulated synovial fibroblasts and in cytokine-induced arthritis in rabbits to investigate its antiinflammatory mechanisms."

"Murine CIA was used to assess the effects of the selective MEK inhibitor on paw edema, clinical scores, weight loss, histopathologic features, and joint levels of p-ERK. Western blotting and immunohistochemistry techniques were used to assess p-ERK in human and rabbit synovial fibroblasts and synovial...

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Source: Fitness and Wellness Business Week (2008-01-02)

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