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Cytomegalovirus
Research in the area of cytomegalovirus reported from L. Cicinsain and colleagues
May 21st, 2008
"Genes that inhibit apoptosis have been described for many DNA viruses. Herpesviruses often contain even more than one gene to control cell death," scientists in Munich, Germany report. "Apoptosis inhibition by viral genes is postulated to contribute to viral fitness, although a formal proof is pending. To address this question, we studied the mouse cytomegalovirus (MCMV) protein M36, which binds to caspase-8 and blocks death receptor-induced apoptosis. The growth of MCMV recombinants lacking M36 (Delta M36) was attenuated in vitro and in vivo. In vitro, caspase inhibition by zVAD-fmk blocked apoptosis in Delta M36-infected macrophages and rescued the growth of the...
Source: Fitness & Wellness Business Week (2008-05-21)
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