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Diabetes
Reports outline diabetes study results from Yamagata University, Medical Department
July 2nd, 2008
"Activation of the diacylglycerol (DAG)-protein kinase C (PKC) pathway has been implicated in the pathogenesis of a number of diabetic complications. Diacylglycerol kinase (DGK) converts DAG to phosphatidic acid and acts as an endogenous regulator of PKC activity," scientists in Yamagata, Japan report. "Akt/PKB is associated with a downstream insulin signaling, and PKC beta attenuates insulin-stimulated Akt phosphorylation. We examined transgenic mice with cardiac-specific overexpression of DGK zeta (DGK zeta-TG) compared to wild type (WT) mice in streptozotocin-induced (STZ, 150 mg/kg) diabetic and nondiabetic conditions. After 8 weeks, decreases in heart weight and...
Source: Fitness & Wellness Business Week (2008-07-02)
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