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Hemorrhagic Shock
Studies from J. Rice et al in the area of hemorrhagic shock described
July 2nd, 2008
"Some hemoglobin-based oxygen carriers (HBOCs) improve outcome in animal models of hemorrhagic shock (HS) in comparison with standard asanguinous resuscitation fluids. Nevertheless, concern about intrinsic vasoactivity, linked in part to low-molecular weight (MW) hemoglobin (Hb), has slowed HBOC development," investigators in the United States report. "We assessed the impact of decreasing the low-MW Hb component of bovine HBOC on vasoactivity in severe HS. Anesthetized invasively monitored swine were hemorrhaged 55% blood volume and resuscitated with bovine HBOC containing 31% (31 TD [HBOC-301]),2% (2 TD [HBOC-201]), or 0.4% (0.4 TD) low-MW Hb. Pigs received four 10...
Source: Fitness & Wellness Business Week (2008-07-02)
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