Published in Fitness and Wellness Business Week, July 9th, 2008
"KIN is expressed in 3T3-L1 cells within 30 min after exposure to a standard adipogenic cocktail of insulin, glucocorticoids, and IBMX. Knockdown of KLF4 inhibits adipogenesis and downregulates C/EBP beta levels. KLF4 binds directly to the C/EBP beta (Cebpb) promoter as shown by chromatin immunoprecipitation and gel shift assays and,...
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