Adipose Tissue

Researchers at Rockefeller University target adipose tissue

Published in Fitness and Wellness Business Week, July 9th, 2008

According to recent research from the United States, "While adipogenesis is known to be controlled by a complex network of transcription factors, less is known about the transcriptional cascade that initiates this process. We report here the characterization of Kruppel-like factor 4 (KLF4) as an essential early regulator of adipogenesis."

"KIN is expressed in 3T3-L1 cells within 30 min after exposure to a standard adipogenic cocktail of insulin, glucocorticoids, and IBMX. Knockdown of KLF4 inhibits adipogenesis and downregulates C/EBP beta levels. KLF4 binds directly to the C/EBP beta (Cebpb) promoter as shown by chromatin immunoprecipitation and gel shift assays and,...

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Source: Fitness and Wellness Business Week (2008-07-09)

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