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Cardiology
Research on cardiology detailed by scientists at Center for Cardiovascular Research
August 20th, 2008
Fresh data on cardiology are presented in the report 'Additional lack of iNOS attenuates diastolic dysfunction in aged ET-1 transgenic mice.' "Endothelin-1 (ET-1) exhibits potent proinflammatory and profibrotic properties. Moreover, inflammation is a potent stimulus for inducible NO synthase (iNOS), which has been shown to contribute to cardiac injury," scientists writing in the Canadian Journal of Physiology and Pharmacology report. "We thus hypothesized that ET-1-induced cardiac injury is attenuated by concomitant lack of iNOS. We established crossbred animals of ET-1 transgenic mice (ET+/+) and iNOS knockout mice (iNOS-/-). At 13 months of age, mice were...
Source: Fitness & Wellness Business Week (2008-08-20)
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