Fitness & Wellness Business Week
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Colitis
Studies from I. Moriyama et al in the area of colitis described
August 20th, 2008
According to recent research published in the journal Laboratory Investigation, "Various therapies are used for inflammatory bowel diseases (IBD), though none seem to be extremely effective. AP-1 is a major transcription factor that upregulates genes involved in immune and proinflammatory responses." "We investigated decoy oligodeoxynucleotide (ODN) targeting AP-1 to prevent dextran sulfate sodium (DSS)-induced colitis in mice. Functional efficacies of synthetic decoy and scrambled ODNs were evaluated in vitro by a reporter gene luciferase assay and measuring flagellin-induced IL-8 expression by HCT-15 cells transfected with ODNs. Experimental colitis was induced...
Source: Fitness & Wellness Business Week (2008-08-20)
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