HIV/AIDS

New findings from Harvard University describe advances in HIV/AIDS

Published in Fitness and Wellness Business Week, April 1st, 2009

"Lamivudine therapy selects for the M184V mutation," investigators in the United States report.

"Although this mutation reduces the replicative capacity of human immunodeficiency virus in vitro, its impact on viral fitness in vivo has not been well defined. We used quantitative allele-specific PCR to precisely calculate the fitness differences between the mutated M184V virus and one that had reverted to the wild type in a cohort of patients by selectively interrupting reverse transcriptase inhibitor therapy, and we found that the M184V variants were consistently 4 to 8% less fit than the wild type in the absence of drug," wrote R. Paredes and colleagues, Harvard...

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Source: Fitness and Wellness Business Week (2009-04-01)

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