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Chinese Academy of Science, Beijing
Poly(acrylic acid) inhibits HIV-1 TAR RNA-Tat peptide interaction
September 24th, 2004
Poly(acrylic acid) inhibits HIV-1 TAR RNA-Tat peptide interaction. According to recent research published in the journal Biochemical and Biophysical Research Communications, "HIV-1 is regulated at the transcriptional level by the interaction of Tat protein with the transactivation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5'-end of all nascent HIV-1 transcripts." "Here, by targeting the Tat peptide," wrote H. Zhao and coauthors, "we found that negatively charged poly(acrylic acid) (PAA) had high affinity with Tat peptide and could inhibit the interaction of TAR with Tat." "Therefore, PAA...
Source: Food & Drug Law Weekly (2004-09-24)
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