Chungbuk National University
Tetrahydropapaverine seen to inhibit serotonin biosynthesis in murine model
Published in Food and Drug Law Weekly, November 5th, 2004
"The inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells were investigated," scientists in South Korea report.
E.I. Kim and colleagues explained, "Tetrahydropapaverine at concentration ranges of 5-20 mcM decreased serotonin content in a concentration-dependent manner in P815 cells and showed 42.1% inhibition of serotonin content at 5.0 mcM at 24 hr. The value of 50% inhibitory concentration, IC50 , of tetrahydropapaverine was 6.2 mcM.
"Under these...
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