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U.S. Food & Drug Administration

Stability of St. John's Wort in aqueous solutions determined

Published in Food and Drug Law Weekly, December 24th, 2004

Researchers have determined the stability of St. John's Wort (Hypericum perforatum) in aqueous solutions.

According to a study from the United States, "Several bioactive botanicals including St. John's wort (SJW; Hypericum perforatum L.) have been used to formulate functional foods and beverages. This study aimed to investigate the stability of SJW components in aqueous solutions and fruit-flavored drinks. Changes of active marker components (hypericin, pseudohypericin, hyperforin, and adhyperforin) as affected by pH and light exposure were determined by HPLC, and the degradation of hyperforin was analyzed by LC-MS/MS and NMR. SJW components were found to...

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