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Concepcion University

 Brucella abortus DNA vaccine was evaluated by expression antigen fusion

Published in Food and Drug Law Weekly, April 21st, 2006

A study from Chile has documented the evaluation of a Brucella abortus DNA vaccine by expression of Cu-Zn superoxide dismutase (SOD) antigen fused to interleukin-2 (IL-2).

"The Cu-Zn SOD antigen of B. abortus was previously identified to be a T cell antigen which induces both proliferation of and gamma interferon (IFN-gamma) secretion by T cells from infected mice. In an earlier study, we demonstrated that intramuscular injection of mice with a plasmid DNA carrying the gene for SOD leads to the development of significant protection against B. abortus challenge," wrote A. Gonzalez-Smith and colleagues of Concepcion University.

"It...

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