Clostridium Toxins

Rac has common and different roles in Fc epsilon RI and M1-receptor signaling

Published in Gastroenterology Week, April 21st, 2003

Large clostridial cytotoxins' action involves different roles of rac in Fc epsilon RI and M1-receptor signaling.

"Using Rho GTPases-inhibiting clostridial cytotoxins, we showed recently in RBL cells that the GTPase Rac is involved in FcepsilonRI (high-affinity receptor for IgE) signaling and receptor-mediated calcium mobilization, including influx via calcium release-activated calcium channels. Here, we studied the role of Rho GTPases in muscarinic M1 receptor signaling in RBL 2H3-hm1 cells.

"Clostridium difficile toxin B, which inactivates Rho, Rac, and Cdc42, and Clostridium sordellii lethal toxin, which inhibits Rac but not Rho,...

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Source: Gastroenterology Week (2003-04-21)

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