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Colon Cancer

Phenethylisothiocyanate induces GADD gene activation in colon cancer cells

Published in Gastroenterology Week, January 19th, 2004

Phenethylisothiocyanate (PEITC) induces DNA damage and GADD153 gene activation, which in turn helps trigger apoptosis in human colon cancer cells, researchers say.

According to published research from the United States, "PEITC, a potential cancer chemopreventive agent, induces colon cancer cell death, but the mechanism is not entirely clear. Therefore, the aim of this study was to further clarify the molecular effects of PEITC in causing death of human colon adenocarcinoma cells.

When incubated with PEITC, HCT-116 colonocytes showed morphological features characteristic of apoptosis, such as irregular cell shape, translocation of plasma membrane...

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