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Gastroenterology Week

Susan Hasty, Publisher

Table of Contents . . . February 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gastroenterology Week | Other Publications

Gastroenterology - Nicotine activates enzymes that provoke gastric cancer growth

Gene Transfer - Hypoxia-inducible therapy halts capillary formation in primary liver cancer

Hematology - Muscle capillary growth is amplified in dialysis patients

Inflammatory Bowel Disease - IL-6 plays pivotal role in transmural inflammation in T cell transfer colitis

Tuberculosis - Retroperitoneal perforation of colon caused by colonic tuberculosis

Anticoagulants - Management varies for patients at risk for bleeding due to anticoagulants

Apoptosis - Rho/rhotekin-mediated NF-kappa B activation confers resistance to apoptosis

Business Update - Pharma companies collaborate to develop new antibody therapeutics

Business Update - Research companies execute commercialization agreement

Cancer Therapy - Phase III data shows Tarceva plus gemcitabine significantly improves survival

Cancer Therapy - Tarceva provides hope for patients with advanced pancreatic cancer

Chemotherapy - Doxorubicin inhibits DNMT1 and results in conditional apoptosis

Choledochal Cyst - Obstetricians should be familiar with choledochal cyst

Collaborations - Pharmaceutical companies agree to jointly commercialize oral cancer drug

Colon Cancer - APC E 1317Q/I1307K germ-line variants not detected in sporadic colon cancer

Colon Cancer - GADD153 protein may be important for curcumin-induced apoptosis

Colon Cancer - Mouse models reveal a novel key player in the initiation of cancer

Colon Cancer - Novel gene CLUAP1 may be biomarker or therapy target

Colon Cancer - Research in colorectal cancer presented at symposium

Colorectal Cancer - Avastin plus FOLFOX4 chemotherapy regimen clinical trial results reported

Colorectal Cancer - Biallelic/monoallelic MYH gene mutations associated with colorectal cancer risk

Colorectal Cancer - Calcium may protect women from colorectal cancer

Colorectal Cancer - Data on assay's ability to predict colorectal cancer treatment outcome presented

Colorectal Cancer - Endpoints met in first stage of CoFactor phase II study in colorectal cancer

Colorectal Cancer - Functional polymorphism in E-cadherin gene associated with colorectal cancer

Colorectal Cancer - PUMA expression changes of minor importance in colorectal cancer development

Crohn Disease - Calcium and vitamin D most effective for treatment of Crohn-related bone loss

Crohn Disease - Inflammation of intestine may signal recurrent acute idiopathic pancreatitis

Cryptosporidium Parvum - Two Cryptosporidium parvum genotypes caused recreational water outbreak

Diabetes Therapy - Adenoviral transfection of islet cells requires a monolayer configuration

Diagnostics - Quantitative biofilm assay/plate screens enteroaggregative E. coli

Diagnostics - Rapid whole-body MRI used to image therapeutic response in bone marrow

Diagnostics - Study recommends at-home colorectal screening tests

Diet & Nutrition - High-protein diets pose risk for patients with chronic kidney disease

Diet & Nutrition - Virtual food components take the guesswork out of healthy eating

Digestion - Phytostanyl ferulate esters are hydrolyzed by pancreatic cholesterol esterase

Endothelial Cell Production - Ursodeoxycholic acid inhibits endothelin-1 production in vascular endothelium

Fatty Liver Disease - Obese young people have a higher risk for developing liver disease

Fibrosis - Review provides information on fibrosis and small bowel carcinoid tumors

Finance - PreGen-Plus maker announces Q4 revenues of $1.3 million

Finance - Provider of medical devices for venous reflux disease reports 4Q 2004 results

Gastroenterology - Gene profiles distinguish pancreatic mucinous cystic neoplasms

Gastroenterology - Spontaneous activity and modulation isolated from guinea-pig stomach antrum

Gastrointestinal Stromal Tumors - Liver transplantation plus imatinib controls gastrointestinal stromal tumors

Gene Expression - Glycolysis genes are ubiquitously overexpressed in 24 cancer classes

Growth Factors - Craniofacial patterning studied, role for fibroblast growth factors revealed

Immunology - Researchers' data advance immunology research

Infections -  Vibrio parahaemolyticus VopA studied, signaling inhibition revealed

Lactobacillus - Aminoglycoside sensitivity in Lactobacillus due to cholic acid

Liver Biopsy - Attenuation/backscatter indices define fatty livers in noninvasive biopsies

Liver Cancer Vaccine - Role of immune system in control of hepatocellular carcinoma reviewed

Liver Transplantation - Inferior mesenteric artery autografts can resolve hepatic artery complications

MALT Lymphoma - MALT lymphoma graded by H. pylori eradication/API2-MALT1 fusion detection

Mycotoxin - Thermal food processing affects structure and toxicity of fumonisin mycotoxins

Neuroscience - Symptoms of sympathetic nervous system may be defensive reactions against nausea

Obesity - Doppler waveform of hepatic veins in obese population examined

Obesity Pathogenesis - Estrogen-related receptor alpha controls lipid handling in intestine

Oncology - High grade liver cancers show no link between telomere length and tumor size

Oncology - Low NEIL1 activity correlates with gastric cancer pathogenesis

Oncology - n-3 Polyunsaturated fatty acids diminish colon cancer angiogenesis

Overactive Bladder - U.S. FDA-approved treatment for overactive bladder now available in the U.S.

Patents - Company wins patent relating to treatment of lower urinary tract disorders

Peptide Transport - Basolateral peptide transporter analyzed, efflux properties revealed

Physiology - Na+/H+ exchange in colonocytes studied, role of zinc receptor revealed

Product Licensing - Company licenses Conversion Technology, Analysis processes to Mayo Medical

Prostate Cancer - CYP3A4*1B/CYP3A43*3 may influence risk of prostate cancer/disease severity

Prostate Cancer - GSTP1 I105V polymorphism not associated with prostate cancer risk

Renal Cell Carcinoma - Body Mass Index linked to increased risk of RCC

Rotavirus Vaccine - Intranasal administration of rotavirus VP6 protein induces protection in mice

Transplant Medicine - Overview provided of FTY720 clinical pharmacokinetics, pharmacology

Vaccine Development - FDA approves human hookworm vaccine for phase I safety trials

Vaccines Safety - Recent findings in vaccines safety described

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