Listeriosis Vaccine
Listeria-infected myeloid dendritic cells activate T cells
Published in Gastroenterology Week, August 22nd, 2005
"The intracellular bacterium Listeria monocytogenes infects dendritic cells (DC) and other APCs and induces potent cell-mediated protective immunity. However, heat-killed bacteria fail to do so. This study explored whether DC differentially respond to live and killed Listeria and how this affects T cell activation," researchers in the United States report.
"To control for bacterial number, a replication-deficient strain, Lmdd, defective in D-alanine biosynthesis, was used," said Hanping Feng and colleagues at Harvard University. "We found that...
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