Published in Gastroenterology Week, November 21st, 2005
"Randomized clinical trials with long-term survival data comparing two treatments often show Kaplan-Meier plots with crossing survival curves. Such behavior implies a violation of the proportional hazards assumption for treatment. The Cox proportional hazards regression model with treatment as a fixed effect can therefore not be used to assess the influence of treatment of survival," researchers in the Netherlands reported.
"In this paper we analyze long-term follow-up data from the Dutch Gastric Cancer Trial, a randomized study comparing...
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