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Adverse Drug Reaction

Reflux treatment linked to life-threatening bowel infection in premature infants

Published in Gastroenterology Week, March 6th, 2006

Premature infants given a common class of non-prescription drugs used to treat acid reflux are slightly more likely to develop a potentially fatal bowel disorder than are infants who are not treated with the drugs.

The drugs, known as H2 blockers, inhibit the production of stomach acid and may put premature infants at risk of necrotizing enterocolitis, a serious inflammation of the intestines.

The findings are from a study published in the February 2006 issue of Pediatrics and conducted by researchers in the U.S. National Institutes of Health (NIH) National Institute of Child Health and Human Development Neonatal Research Network.

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