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Cancer Risk Factors
Cancer risks linked to LKB1 germline mutation carriers
August 7th, 2006
Investigators detailed the age related cumulative risks of developing cancer in LKB1 mutation carriers. "Germline mutations in the LKB1 gene are known to cause Peutz-Jeghers syndrome, which is an autosomal dominant disorder characterised by hamartomatous polyposis and mucocutaneous pigmentation. This syndrome is associated with an increased risk of malignancies in different organs but there is a lack of data on cancer range and risk in LKB1 germline mutation carriers," scientists in Switzerland reported. "The cumulative incidence of cancer in 149 Peutz-Jeghers syndrome patients with germline mutation(s) in LKB1 was estimated using Kaplan-Meier time...
Source: Gastroenterology Week (2006-08-07)
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