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Colon Cancer
DP1 plays tumor suppressor role in colon carcinogenesis
August 7th, 2006
A human cervical cancer oncogene 1-interacting molecule, called deleted in polyposis 1 (DP1), was implicated as a tumor-suppressor in colon cancer (CRC). "Human cervical cancer oncogene (HCCR-1) has appeared to act as a negative regulator of p53 and contributes to tumorigenesis of various organs including the colon. We identified the HCCR-1 binding protein DP1 and accessed the role of HCCR-1 and DP1 in colon tumorigenesis. Yeast 2-hybrid was used to identify HCCR-1 interacting proteins," scientists writing in the journal Gastroenterology reported. "Various molecular biological approaches were used to examine the expression profile of HCCR-1...
Source: Gastroenterology Week (2006-08-07)
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