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Colorectal Cancer
Colorectal cancer methylator phenotype linked to JC virus T-antigen expression
August 7th, 2006
The methylator phenotype in colorectal cancers (CRCs) could be associated with JC virus (JCV) T-antigen (T-Ag) expression through multiple mechanisms of genetic and epigenetic instability. "JCV is a polyomavirus that ubiquitously infects humans and has been implicated in various human cancers. JCV encodes a 'transforming' gene, T-Ag, which is believed to mediate the oncogenic potential of the virus," scientists in the United States reported. "We have previously shown that JCV DNA sequences are usually present in human CRCs, and we have provided in vitro evidence that JCV can induce chromosomal instability (CIN) in CRC cells," explained M. Goel and...
Source: Gastroenterology Week (2006-08-07)
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