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Colorectal Cancer
Colorectal cancer proliferation inhibited by Gli1 via Wnt signaling activation
August 7th, 2006
Colorectal cancer proliferation could be inhibited by Gli1 via Wnt signaling activation. "Early events in the progression of 90% of sporadic colorectal cancers depend on constitutive activation of Wnt signalling. Recent data also indicate a close association between the Hedgehog (Hh) and Wnt pathways in colonic epithelial cell differentiation," investigators in Japan reported. "[The study's aim was] to investigate whether expression of Gli1, a transactivator of Hh signalling, can suppress Wnt signalling and inhibit proliferation of human colorectal cancer cells," explained T. Akiyoshi and colleagues, Kyushu University. "Gli1 and nuclear beta-catenin...
Source: Gastroenterology Week (2006-08-07)
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