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Colorectal Cancer
Colorectal cancers with altered beta-catenin produce excess securin
August 7th, 2006
Colorectal cancers with altered beta catenin produce excess securin. According to a study from Germany, "Overexpression of the transcriptional activator beta-catenin, mostly owing to loss-of-function mutations of the adenomatous polyposis coli (APC) tumor suppressor gene, is crucial for the initiation and progression of human colorectal carcinogenesis." "Securin is a regulator of chromosome separation and its overexpression has been shown to be involved in different tumour-promoting processes, like transformation, hyperproliferation and angiogenesis, and correlates with tumor cell invasion," said F. Hlubek and colleagues, University of Munich. ...
Source: Gastroenterology Week (2006-08-07)
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