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Colorectal Cancer
Non-Lynch syndrome patients should also undergo colonoscopic surveillance, but at longer intervals
August 7th, 2006
Non-Lynch syndrome patients should also undergo colonoscopic surveillance because individuals with a family history of colorectal cancer with and without evidence of Lynch syndrome are at equal risk of high-risk adenomas. According to a study from England, "Lynch syndrome is an autosomal dominant predisposition to colorectal cancer caused by mutations in DNA mismatch repair genes; colorectal cancer risk is high. Few studies have addressed colorectal cancer risk in individuals from dominant families without mismatch repair deficiency." "We sought to establish whether these individuals are also at increased risk by examining the incidence of advanced...
Source: Gastroenterology Week (2006-08-07)
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