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Developmental Biology
Hepatic stellate cell growth inhibited by a receptor
August 7th, 2006
In a recently published study, investigators from the People's Republic of China reported that peroxisome proliferator-activated receptor (PPAR) gamma inhibits growth of rat hepatic stellate cells (HSC) and tissue growth factor (TGF) beta-induced connective tissue growth factor (CTGF) expression. K. Sun and colleagues, Sun Yat Sen University, wrote that the study was done, "to investigate the effect of PPAR gamma activation on the growth of rat HSC and TGF-beta-induced CTGF expression." "After being treated with various amounts of the PPAR gamma natural ligand 15-deoxy-A12,14-prostaglandin J(2) (15-d-PGJ(2)) or synthetic ligand GW7845, the status of...
Source: Gastroenterology Week (2006-08-07)
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