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Diabetes Epidemiology
FOX01A variation is rare and unlikely to contribute to type 2 diabetes mellitus
August 7th, 2006
The FOX01A variation is rare and is unlikely to contribute to type 2 diabetes mellitus. According to recent research from the United States, "The human forkhead box O1A (FOXO1A) gene on chromosome 13q14.1 is a key transcription factor in insulin signaling in liver and adipose tissue and plays a central role in the regulation of key pancreatic beta-cell genes including IPF1." M.A. Karim and colleagues at the University of Arkansas for Medical Sciences hypothesized "sequence variants of FOXO1A contribute to the observed defects in hepatic and peripheral insulin action and altered beta-cell compensation that characterize type 2 diabetes (T2DM). To test...
Source: Gastroenterology Week (2006-08-07)
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