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Diabetes Pathogenesis
H2 O2 - and alloxan-related pancreatic cell death was not linked to acidification
August 7th, 2006
H2 O2 - and alloxan-related pancreatic cell death was not linked to acidification. According to recent research from Japan, "Pancreatic beta-cell death induced by oxidative stress plays an important role in the pathogenesis of diabetes mellitus. We studied the relation between rapid intracellular acidification and cell death of pancreatic beta-cell line NIT-I cells exposed to H2 O2 or alloxan. Intracellular pH was measured by a pH-sensitive dye and cell damage by double staining with Annexin-V and propidium iodide using flow cytometry." U. Nakamura and colleagues at Kyushu University determined,...
Source: Gastroenterology Week (2006-08-07)
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