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Diabetes Pathogenesis
Mercury-induced oxidative stress and phosphoinositide 3-kinase promote beta-cell dysfunction
August 7th, 2006
Mercury-induced oxidative stress and phosphoinositide 3-kinase activation cause Akt signaling-related pancreatic beta-cell dysfunction. "The relationship between oxidation stress and phosphoinositide 3-kinase (PI3K) signaling in pancreatic beta-cell dysfunction remains unclear. Mercury is a well-known toxic metal that induces oxidative stress," scientists writing in the journal Diabetes report. Y.W. Chen and colleagues working with the National Taiwan University determined, "Submicromolar-concentration HgCl2 or methylmercury triggered reactive oxygen species (ROS) production and decreased insulin secretion in beta-cell-derived...
Source: Gastroenterology Week (2006-08-07)
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