Pancreatitis
Chronic pancreatitis is inhibited by a degradation-sensitive anionic trypsinogen
Published in Gastroenterology Week, August 7th, 2006
"Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) 1 and the pancreatic secretory trypsin inhibitor (SPINK1) 2 are associated with chronic pancreatitis.
"Because increased proteolytic activity owing to mutated PRSS1 enhances the risk for chronic pancreatitis, mutations in the gene encoding anionic trypsinogen (PRSS2) may also predispose to disease," wrote H. Witt and colleagues, University Hospital Berlin.
"Here we analyzed...
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