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Pancreatitis
Chronic pancreatitis is inhibited by a degradation-sensitive anionic trypsinogen
August 7th, 2006
According to recent research from Germany, chronic pancreatitis is inhibited by a degradation-sensitive anionic trypsinogen. "Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) 1 and the pancreatic secretory trypsin inhibitor (SPINK1) 2 are associated with chronic pancreatitis. "Because increased proteolytic activity owing to mutated PRSS1 enhances the risk for chronic pancreatitis, mutations in the gene encoding anionic trypsinogen (PRSS2) may also predispose to disease," wrote H. Witt and colleagues, University Hospital Berlin. "Here we analyzed...
Source: Gastroenterology Week (2006-08-07)
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