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Gastroenterology Week

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Disease Associations



Macrophage activating syndrome is associated with lobular hepatitis



August 7th, 2006

According to a study from Switzerland, macrophage activating syndrome (MAS) is associated with lobular hepatitis and severe bile duct injury with cholestasis.

"MAS is a rare hematological disorder associated with uncontrolled systemic T-cell activation. Persistent fever, fatigue and hepatosplenomegaly are frequent clinical manifestations, whereas hyperferritinemia, elevated serum lactate dehydrogenase levels and cytopenia are key criteria for the diagnosis of MAS.

"The nature of liver pathology in MAS has been partially elucidated but destructive biliary lesions have been rarely described. This report illustrates four cases of MAS developing marked...


Source: Gastroenterology Week (2006-08-07)

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