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Drug Development
Novel synthesis of nicotinamide derivatives with cytotoxic properties described
August 7th, 2006
The novel synthesis of nicotinamide derivatives with cytotoxic properties was described. According to recent research published in the journal Bioorganic & Medicinal Chemistry, "A variety of 2-substituted-4,6-diaryl-3-pyridinecarboxamides 5 were synthesized through aromatic nucleophilic substitution reaction of secondary amines with 2-bromo analogues 4. The latter were obtained via bromination of 2-cyano-3,5-diaryl-5-oxo-N-substituted pentamides 3 in glacial acetic acid." "Moreover, pentamide derivatives 3 were prepared through base-catalyzed Michael addition of cyanacetanilides 2 with 1,3-diaryl-2-propen-l-ones 1," explained A.S. Girgis and...
Source: Gastroenterology Week (2006-08-07)
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