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Endocrinology
Hepatic glucose defects in type 2 diabetes reverses upon correcting free fatty acid levels
August 7th, 2006
Loss of hepatic glucose effectiveness in type 2 diabetes is reversible upon correcting the free fatty acid levels. According to recent research from the United States, "Impaired effectiveness of glucose to suppress endogenous glucose production (EGP) is an important cause of worsening hyperglycemia in type 2 diabetes. Elevated free fatty acids (FFAs) may impair glucose effectiveness via several mechanisms, including rapid changes in metabolic fluxes and/or more gradual changes in gene expression of key enzymes or other proteins. Thus, we examined the magnitude and time course of effects of FFAs on glucose effectiveness in type 2 diabetes and whether glucose...
Source: Gastroenterology Week (2006-08-07)
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