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Endocrinology
Metformin contributes to glucose-6-phosphatase drop in liver
August 7th, 2006
Metformin contributes to a reduction of glucose-6-phosphatase in the liver thereby controlling blood glucose. According to a study from Japan, "Metformin is widely used as a hypoglycaemic reagent for type 2 diabetes. While the reduction of hepatic gluconeogenesis is thought to be a key effect, the detailed molecular mechanism of action of metformin remains to be elucidated. To gain insight into this, we performed a global gene expression profiling study." M. Heishi and colleagues at Dainippon Sumitomo Pharma performed "DNA microarray analysis to study global gene expression in the livers of obese diabetic db/db mice 2 h after a single administration...
Source: Gastroenterology Week (2006-08-07)
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